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Impairment of Nrf2/ARE signaling has been observed in HCV infection, leading to elevated ROS levels that can activate autophagy and facilitate HCV maturation and release 103,104

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Lowering the limit to 0.05% could potentially save nearly 1,800 lives per year, based on a 2017 analysis

Nevertheless, these factors were excluded from our investigation and reduced Zn amounts of infertile patients can be explained by other mechanisms

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